Barx2^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Barx2^tm1Rsd
• Name: BarH-like homeobox 2; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:3574438
• Synonyms: Barx2^-
• Gene: Barx2 Location: Chr9:31757340-31824581 bp, - strand Genetic Position: Chr9, 17.25 cM
• Alliance: Barx2^tm1Rsd page

Barx2^tm1Rsd/Barx2^tm1Rsd mice display open eyelids at birth, abnormal hair follicle remodeling and short whiskers and hair

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-PGK-neo replaced the 3' end of exon 2 and all of exon 3. The deleted sequence encoded the homeodomain and C-terminal sequence. RT-PCR of mutant skin samples demonstrated the loss of 3' message. The truncated transcript consisted of a 134 amino acid epitope fused in frame to Beta-galactosidase. (J:96883)

Disease models

Expression

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Barx2 Mutation: 26 strains or lines available

References

• Original: J:96883 Olson LE, et al., Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3708-13
• All: 6 reference(s)