Xab2^tm2Tnka
Targeted Allele Detail

Summary

• Symbol: Xab2^tm2Tnka
• Name: XPA binding protein 2; targeted mutation 2, Kiyoji Tanaka
• MGI ID: MGI:3574460
• Synonyms: XAB2^-cd
• Gene: Xab2 Location: Chr8:3660089-3671311 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Xab2^tm2Tnka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96962
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A targeting vector was designed to delete the C-terminal 162 amino acids by replacing the 3' end of exon 14 and all of exons 15-19 with human HBB cDNA for exons 2 and 3. (J:96962)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xab2 Mutation: 37 strains or lines available

References

• Original: J:96962 Yonemasu R, et al., Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality. DNA Repair (Amst). 2005 Apr 4;4(4):479-91
• All: 1 reference(s)