Arfix^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Arfix^C57BL/6J
• Name: antibody response to human factor IX; C57BL/6J
• MGI ID: MGI:3574487
• QTL: Arfix Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96612

Antibody response to factor VIII and factor IX is a complication to treatments for hemophilia A and hemophilia B. Loci associated with antibody response to human factor IX were mapping using mouse models. Human factor IX was expressed in 26 AXB and BXA recombinant inbred strains using an adenoviral vector. Parental strain C57BL/6J is a low antibody responder to human factor IX whereas parental strain A/J is a high antibody responder. Linkage analysis was performed using a panel of 753 polymorphic markersmapped between A/J and C57BL/6J.

Significant linkage to antibody response to human factor IX mapped to 17.4 cM on mouse Chromosome 17 near D17Mit62 with LOD=4.8. This locus is designated Arfix (antibody response to human factor IX). Arfiv maps very close to the H2 locus.

Suggestive linkage to anti-human factor IX mapped to 71 cM on mouse Chromosome 1 near D1Mit100 with LOD=2.6. Genes mapping to this region include Il10 (69.9 cM) and Ptprc (74 cM). Previously identified immune response QTLs mapping nearthis locus are Tir3b (71 cM), Sle8 (71.4 cM), and Ity2 (71.5).

Suggestive linkage to anti-human factor IX mapped to 64 cM on mouse Chromosome 10 near D10Mit180 with LOD=2.3. Genes mapping to this region are Ifng (67 cM), Il22 (67 cM), and Tmevp2 (67 cM).

References

• Original: J:96612 Lozier JN, et al., Mapping of genes that control the antibody response to human factor IX in mice. Blood. 2005 Feb 1;105(3):1029-35
• All: 1 reference(s)