Gct4^CAST/Ei
QTL Variant Detail

Summary

• QTL variant: Gct4^CAST/Ei
• Name: granulosa cell tumorigenesis 4; CAST/Ei
• MGI ID: MGI:3574519
• QTL: Gct4 Location: ChrX:76124336-102062720 bp Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: CAST/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to granulosa cell turmor formation compared to SWR. (J:87114)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:49710

The authors analyzed three matings for genetic analysis to identify QTLs responsible for tumor susceptibility. 1) F2 female progeny from four reciprocal F1 x F1 intercrosses [cross A. (SJL x SWR)F1 x (SJL x SWR)F1; cross B. (SJL x SWR)F1 x (SWR x SJL)F1;cross C. (SWR x SJL)F1 x (SJL x SWR)F1; cross D. (SWR x SJL)F1 x (SWR x SJL)F1]. 2) The SWR congenic strains [SWR.SJL-X1, SWR.SJL-X2, SWR.SJL-X3, SWR.SJL-X4] containing most of Chromosome X from DXMit55 to DXMit182 and 3)SW x J RI strains. They were ableto identify a SJL derived susceptibility allele on mouse Chromosome X associated with DXMit16. The authors suggest that DXMit16 is not sufficient for tumorigenesis without the SWR susceptibility allele linked to D4Mit232. The authors also identified a parent of origin effect associated with the paternal allele of DXMit16 (chi square = 9.22; P<0.001). Thus females that inherited the SJL allele from the father have higher tumor incidences than those that inherit the allele from their mothers. An interesting candidate gene for Gct4 is the Ar locus which maps less than 1 cM proximal to DXMit16.

References

• Original: J:87114 Dorward AM, et al., High-resolution genetic map of X-linked juvenile-type granulosa cell tumor susceptibility genes in mouse. Cancer Res. 2003 Dec 1;63(23):8197-202
• All: 1 reference(s)