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Ralgdstm1Cjm
Targeted Allele Detail
Summary
Symbol: Ralgdstm1Cjm
Name: ral guanine nucleotide dissociation stimulator; targeted mutation 1, Christopher J Marshall
MGI ID: MGI:3574574
Synonyms: RalGDS-, RalGDSn
Gene: Ralgds  Location: Chr2:28403137-28443093 bp, + strand  Genetic Position: Chr2, 19.38 cM, cytoband A3
Alliance: Ralgdstm1Cjm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:96936
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 9-15, which make up part of the catalytic domain, were removed via cre-mediated recombination. Northern blot of mutant MEFs confirmed the lack of transcript. (J:96936)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Tumor Data
List all tumor models in MMHCdb carrying Ralgdstm1Cjm
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ralgds Mutation:  52 strains or lines available
References
Original:  J:96936 Gonzalez-Garcia A, et al., RalGDS is required for tumor formation in a model of skin carcinogenesis. Cancer Cell. 2005 Mar;7(3):219-26
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory