Lmo4^tm1.1Gng
Targeted Allele Detail

Summary

• Symbol: Lmo4^tm1.1Gng
• Name: LIM domain only 4; targeted mutation 1.1, Gordon N Gill
• MGI ID: MGI:3574586
• Synonyms: Lmo4^-
• Gene: Lmo4 Location: Chr3:143894291-143910981 bp, - strand Genetic Position: Chr3, 68.61 cM
• Alliance: Lmo4^tm1.1Gng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96957
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 1b and 2 were removed via cre-mediated recombination. This sequence contains the translation start site and N-terminal LIM domain. Immunohistochemical staining confirmed absence of protein in cervical spinal cord sections of mutants. (J:96957)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo4 Mutation: 9 strains or lines available

References

• Original: J:96957 Lee SK, et al., The LIM domain-only protein LMO4 is required for neural tube closure. Mol Cell Neurosci. 2005 Feb;28(2):205-14
• All: 5 reference(s)