Eef1e1^{Gt(OST377244)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Eef1e1^{Gt(OST377244)Lex}
• Name: eukaryotic translation elongation factor 1 epsilon 1; gene trap OST377244, Lexicon Genetics
• MGI ID: MGI:3574590
• Synonyms: Eef1e1^Gt1Skim, p18^-
• Gene: Eef1e1 Location: Chr13:38829667-38843004 bp, - strand Genetic Position: Chr13, 18.38 cM, cytoband A5
• Alliance: Eef1e1^{Gt(OST377244)Lex} page

Mutation origin

• Mutant Cell Line: OST377244
• Germline Transmission: Earliest citation of germline transmission: J:96923
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted between exons 1 and 2. Western blot of heterozygous small intestine, kidney, heart and spleen samples demonstrated a decrease in protein. (J:96923)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST377244	CG641886 ; (MGI Seq Detail)	3' RACE	Chr13:38839835-38840217 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  15 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Tumor Data

List all tumor models in MMHCdb carrying Eef1e1^{Gt(OST377244)Lex}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef1e1 Mutation: 19 strains or lines available

References

• Original: J:96923 Park BJ, et al., The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR. Cell. 2005 Jan 28;120(2):209-21
• All: 2 reference(s)