Hrk^tm1Nnz
Targeted Allele Detail

Summary

• Symbol: Hrk^tm1Nnz
• Name: harakiri, BCL2 interacting protein (contains only BH3 domain); targeted mutation 1, Gabriel Nunez
• MGI ID: MGI:3574591
• Synonyms: DP5^-
• Gene: Hrk Location: Chr5:118307829-118327543 bp, + strand Genetic Position: Chr5, 58.16 cM, cytoband F
• Alliance: Hrk^tm1Nnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96893
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The single coding exon was replaced with a neomycin resistance cassette. RT-PCR of mutant brain, spleen, thymus, bone marrow and liver samples demonstrated the lack of transcript. (J:96893)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hrk Mutation: 0 strains or lines available

References

• Original: J:96893 Imaizumi K, et al., Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death. J Neurosci. 2004 Apr 14;24(15):3721-5
• All: 5 reference(s)