Hgf^tm1Jmw
Targeted Allele Detail

Summary

• Symbol: Hgf^tm1Jmw
• Name: hepatocyte growth factor; targeted mutation 1, James M Wilson
• MGI ID: MGI:3574633
• Synonyms: HGF^ex.5-flox
• Gene: Hgf Location: Chr5:16758493-16825150 bp, + strand Genetic Position: Chr5, 7.07 cM, cytoband A2-A3
• Alliance: Hgf^tm1Jmw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97145
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 4 and a loxP-flanked neomycin-thymidine kinase selection cassette into intron 5 of the gene. The loxP sites flank a region of the gene encoding most of the first kringle domain necessary for the biological activity of the corresponding protein. Transient Cre recombinase transfection removed the selection cassette prior to the production of chimeric mice. (J:97145)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hgf Mutation: 55 strains or lines available

References

• Original: J:97145 Phaneuf D, et al., Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration. DNA Cell Biol. 2004 Sep;23(9):592-603
• All: 11 reference(s)