Vipr2^tm1Ajh
Targeted Allele Detail

Summary

• Symbol: Vipr2^tm1Ajh
• Name: vasoactive intestinal peptide receptor 2; targeted mutation 1, Andrew J Harmar
• MGI ID: MGI:3574664
• Synonyms: Vipr2^-, VPAC2^-, VPAC2R-null
• Gene: Vipr2 Location: Chr12:116041346-116109881 bp, + strand Genetic Position: Chr12, 62.59 cM, cytoband F2
• Alliance: Vipr2^tm1Ajh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72933
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector containing nls-lacZ-PA-TK-neo replaced 132 bp of sequence in exon 1, which contains the translation start site. RT-PCR confirmed ablation of wild-type transcript and no lacZ expression was detected in mutants. (J:72933)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vipr2 Mutation: 31 strains or lines available

Notes

ES cell line = E14/4.

References

• Original: J:72933 Goetzl EJ, et al., Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13854-9
• All: 32 reference(s)