Rps6ka5^tm1Jsca
Targeted Allele Detail

Summary

• Symbol: Rps6ka5^tm1Jsca
• Name: ribosomal protein S6 kinase, polypeptide 5; targeted mutation 1, J Simon C Arthur
• MGI ID: MGI:3574760
• Synonyms: MSK1^-
• Gene: Rps6ka5 Location: Chr12:100514692-100691693 bp, - strand Genetic Position: Chr12, 50.81 cM
• Alliance: Rps6ka5^tm1Jsca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97140
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo was inserted to replace the ATG and delete the 3' end of exon 1. Western blot of mutants confirmed absence of protein in mutant MEFs. (J:97224)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rps6ka5 Mutation: 64 strains or lines available

References

• Original: J:97140 Wiggin GR, et al., MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol. 2002 Apr;22(8):2871-81
• All: 35 reference(s)