Lif^tm1Cgre
Targeted Allele Detail

Summary

• Symbol: Lif^tm1Cgre
• Name: leukemia inhibitory factor; targeted mutation 1, Centre for Genome Research
• MGI ID: MGI:3574767
• Synonyms: LIF^-
• Gene: Lif Location: Chr11:4207587-4222514 bp, + strand Genetic Position: Chr11, 2.94 cM, cytoband A1-A2
• Alliance: Lif^tm1Cgre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97139
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding sequence was deleted and replaced by an Hprt minigene driven by the Prkg1 promoter. (J:97139)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lif Mutation: 11 strains or lines available

References

• Original: J:97139 Dani C, et al., Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev Biol. 1998 Nov 1;203(1):149-62
• All: 5 reference(s)