Slc18a2^tm1Edw
Targeted Allele Detail

Summary

• Symbol: Slc18a2^tm1Edw
• Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, Robert H Edwards
• MGI ID: MGI:3574768
• Synonyms: VMAT2^-, VMAT2KO
• Gene: Slc18a2 Location: Chr19:59249328-59284444 bp, + strand Genetic Position: Chr19, 54.64 cM
• Alliance: Slc18a2^tm1Edw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:45183
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first and second protein coding exons were replaced with a neomycin resistance gene. Western blot analysis and quantitation of protein by tetrabenzine binding of mutant membrane vesicles confirmed absence of protein. (J:45183)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc18a2 Mutation: 29 strains or lines available

References

• Original: J:45183 Fon EA, et al., Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action. Neuron. 1997 Dec;19(6):1271-83
• All: 5 reference(s)