Txnrd1^tm1.1Marc
Targeted Allele Detail

Summary

• Symbol: Txnrd1^tm1.1Marc
• Name: thioredoxin reductase 1; targeted mutation 1.1, Marcus Conrad
• MGI ID: MGI:3574773
• Synonyms: Txnrd1^-
• Gene: Txnrd1 Location: Chr10:82669785-82733546 bp, + strand Genetic Position: Chr10, 40.66 cM
• Alliance: Txnrd1^tm1.1Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96818
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 15, which encodes 22 amino acids and the C-terminally located redox center consisting of Gly-Cys-Sec-Gly, and 1.7 kb of the 3' UTR containing the selenocysteine insertion element, essential for cotranslational Sec incorporation at the UGA codon, AU-rich mRNA instability elements and the endogenous transcription stop signal, were deleted from Txnrd1^tm1Marc via cre-mediated recombination. RT-PCR confirmed the excision of exon 15 in embryonic mRNAs from E9.5 (J:96818)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txnrd1 Mutation: 49 strains or lines available

References

• Original: J:96818 Jakupoglu C, et al., Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development. Mol Cell Biol. 2005 Mar;25(5):1980-8
• All: 2 reference(s)