Fgfr1^Hspy
Chemically induced Allele Detail

Summary

• Symbol: Fgfr1^Hspy
• Name: fibroblast growth factor receptor 1; hush puppy
• MGI ID: MGI:3574787
• Synonyms: DEA9
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^Hspy page

E8.5 Fgfr1^Hspy/Fgfr1^Hspy embryos show a restriction at the embryonic/extra-embryonic boundary (arrow)

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU-mutagenesis induced a T to A transversion in exon 15 that results in the amino acid substitution of arginine for tryptophan at position 691 (W691R). Reduced transcript expression was confirmed by RT-PCR. (J:82809, J:171915) Inheritance: Not Specified

Identification of the mutation in Fgfr1^Hspy

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:95895 Pau H, et al., Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects. Laryngoscope. 2005 Jan;115(1):116-24
• All: 5 reference(s)