Zic5tm1Sia
Targeted Allele Detail
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Symbol: |
Zic5tm1Sia |
Name: |
zinc finger protein of the cerebellum 5; targeted mutation 1, Shinichi Aizawa |
MGI ID: |
MGI:3574814 |
Synonyms: |
Opr- |
Gene: |
Zic5 Location: Chr14:122696572-122703127 bp, - strand Genetic Position: Chr14, 65.96 cM, cytoband E5
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Alliance: |
Zic5tm1Sia page
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: A sequence 172 bp upstream of the zinc finger motif at exon 1 was replaced with a cassette containing stop-IRES-lacZ-loxP-neo-loxP. RT-PCR of mutant embryos confirmed absence of transcript. Crossing with EIIa-cre mice removed the neo.
(J:97076)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: C57BL/6 * CBA | |
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Phenotypes: |
Affected Systems |
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craniofacial
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absent mandible
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micrognathia
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growth/size/body
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microcephaly
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√
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mortality/aging
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neonatal lethality, complete penetrance
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nervous system
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abnormal forebrain development
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abnormal hippocampus development
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abnormal telencephalon development
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√
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abnormal folding of telencephalic vesicles
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dilated lateral ventricle
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abnormal choroid plexus morphology
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dilated third ventricle
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√
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abnormal globus pallidus morphology
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abnormal striatum morphology
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abnormal hypothalamus morphology
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small thalamus
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abnormal cerebral cortex morphology
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exencephaly
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abnormal axon morphology
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abnormal cranial ganglia morphology
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abnormal glossopharyngeal ganglion morphology
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abnormal trigeminal ganglion morphology
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skeleton
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absent mandible
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√
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micrognathia
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√
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vision/eye
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√
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abnormal optic vesicle formation
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√
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microphthalmia
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√
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anophthalmia
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:97076 Furushima K, et al., Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn. 2005 Apr;232(4):1056-61 |
All: |
2 reference(s) |
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