Summary |
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Mutation origin |
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Mutation description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Expression |
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Find Mice (IMSR) |
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Notes |
Northern blot analysis of liver RNA and immunoblot analysis of plasma from homozygous mice demonstrated lack of expression of Apoe RNA and protein. The phenotype is generally similar to that of targeted Apoe mutations on the same diet. Mice of the original mutant strain (SHL) exhibit more severe xanthoma and hypercholesterolemia, and at an earlier age, than do homozygous mice congenic for the mutation on three standard laboratory inbred-strain backgrounds. In contrast, atherosclerotic lesions of the aortae of congenic mutants are more extensive than those of SHL mice. SHL mice seldom survive past 12 months of age.
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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