Gstml^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Gstml^C57BL/6J
• Name: gestational survival modifier locus; C57BL/6J
• MGI ID: MGI:3574914
• QTL: Gstml Location: unknown Genetic Position: Chr2, cM position of peak correlated region/allele: 77.36 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased embryo survival in the presence of the Hba-x^tm1Led mutation compared to 129S/SvEm. (J:96394)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:96394

Animals homozygous for the Hba-x^tm1Led mutation on a 129S/SvEv genetic background do not survive gestation. However, homozygous mutants on a C57BL/6J genetic background do survive gestation. In order to map genes modifying embryonic survival approximately 115 polymorphic markers were genotyped in 97 Hba-x^tm1Led homozygous (129S/SvEv-Hba-x^tm1Led x C57BL/6J)F1 x 129S/SvEv-Hba-x^tm1Led backcross animals and 105 littermate controls.

Linkage to embryonic survival mapped to 87 cM on mouse Chromosome 2near D2Mit48 (P<0.0014) and 70 cM on mouse Chromosome 5 near D5Mit161 (P<0.032). The chromosome 2 locus is named Gstml (gestational survival modifier locus). The chromosome 5 locus did not reach statistical criteria to declare linkage. C57BL/6J-derived alleles confer increased embryo survival at the chromosome 2 and chromosome 5 loci. Interestingly, these loci are also associated with loss of heterozygosity (LOH) in surviving homozygous mutant animals.

References

• Original: J:96394 Leder A, et al., zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. Hum Mol Genet. 2005 Mar 1;14(5):615-25
• All: 1 reference(s)