Nfe2l1^tm1Jefc
Targeted Allele Detail

Summary

• Symbol: Nfe2l1^tm1Jefc
• Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Jefferson Y Chan
• MGI ID: MGI:3574931
• Synonyms: Nrf1^flox
• Gene: Nfe2l1 Location: Chr11:96708240-96720794 bp, - strand Genetic Position: Chr11, 60.12 cM, cytoband D-E
• Alliance: Nfe2l1^tm1Jefc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97188
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 3 and a PGK-1 promoter-driven neomycin resistance gene cassette followed by a 3' loxP site was inserted downstream of the terminal exon 4. An IRES-GFP was at the 3' end of the neo. (J:97188)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfe2l1 Mutation: 42 strains or lines available

References

• Original: J:97188 Xu Z, et al., Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4120-5
• All: 3 reference(s)