Dnmt3l^tm1Scot
Targeted Allele Detail

Summary

• Symbol: Dnmt3l^tm1Scot
• Name: DNA methyltransferase 3-like; targeted mutation 1, Hamish S Scott
• MGI ID: MGI:3574947
• Synonyms: Dnmt3L^-
• Gene: Dnmt3l Location: Chr10:77878121-77899456 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dnmt3l^tm1Scot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97190
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 5 was disrupted by the insertion of a lacZ and floxed neo into the plant homeodomain-like zinc finger domain. Crossing mice to a strain expressing cre in the germ line removed the neo. (J:97190)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3l Mutation: 52 strains or lines available

References

• Original: J:97190 Webster KE, et al., Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4068-73
• All: 3 reference(s)