Umod^tm1Kuma
Targeted Allele Detail

Summary

• Symbol: Umod^tm1Kuma
• Name: uromodulin; targeted mutation 1, Satish Kumar
• MGI ID: MGI:3574985
• Synonyms: THP^-
• Gene: Umod Location: Chr7:119061931-119078485 bp, - strand Genetic Position: Chr7, 63.88 cM, cytoband F1-F2
• Alliance: Umod^tm1Kuma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97228
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neo interrupted the coding sequence in exon 2. Northern and Western blot as well as immunocytochemistry confirmed absence of transcript and protein in mutant mice. (J:97228)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Umod Mutation: 5 strains or lines available

References

• Original: J:97228 Bates JM, et al., Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int. 2004 Mar;65(3):791-7
• All: 8 reference(s)