Gnaz^tm1Iah
Targeted Allele Detail

Summary

• Symbol: Gnaz^tm1Iah
• Name: guanine nucleotide binding protein, alpha z subunit; targeted mutation 1, I A Hendry
• MGI ID: MGI:3575007
• Synonyms: Gzalpha^-
• Gene: Gnaz Location: Chr10:74803009-74852739 bp, + strand Genetic Position: Chr10, 38.48 cM
• Alliance: Gnaz^tm1Iah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63129
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The alpha subunit was ablated by the insertion of a PGK-neo cassette 160 bp downstream of the translation start site. Aplha subunit protein was absent in Western blots of brains and other tissues of mutant mice. (J:63129)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gnaz Mutation: 18 strains or lines available

References

• Original: J:63129 Hendry IA, et al., Hypertolerance to morphine in G(z alpha)-deficient mice. Brain Res. 2000 Jul 7;870(1-2):10-9
• All: 11 reference(s)