Brsk2^tm1Jrs
Targeted Allele Detail

Summary

• Symbol: Brsk2^tm1Jrs
• Name: BR serine/threonine kinase 2; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:3575113
• Synonyms: sada^-, sada^ex1
• Gene: Brsk2 Location: Chr7:141503488-141557981 bp, + strand Genetic Position: Chr7, 87.43 cM, cytoband F5
• Alliance: Brsk2^tm1Jrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96030
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP-flanked neomycin resistance gene replaced the first coding exon. Northern blot of mutant brain samples demonstrated the lack of transcript. (J:96030)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brsk2 Mutation: 37 strains or lines available

References

• Original: J:96030 Kishi M, et al., Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11;307(5711):929-32
• All: 6 reference(s)