Ly75^tm1Mnz
Targeted Allele Detail

Summary

• Symbol: Ly75^tm1Mnz
• Name: lymphocyte antigen 75; targeted mutation 1, Michel C Nussenzweig
• MGI ID: MGI:3575119
• Synonyms: DEC-205^-, DEC205 ko, DEC-205^null
• Gene: Ly75 Location: Chr2:60122447-60213617 bp, - strand Genetic Position: Chr2, 34.54 cM
• Alliance: Ly75^tm1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97292
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was used to disrupt the promoter and exon 1. Flow cytometry analysis of activated T cells does not detect a functional gene product (protein). (J:97292)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ly75 Mutation: 78 strains or lines available

References

• Original: J:97292 Guo M, et al., A monoclonal antibody to the DEC-205 endocytosis receptor on human dendritic cells. Hum Immunol. 2000 Aug;61(8):729-38
• All: 25 reference(s)