Rasa3^hlb381
Chemically induced Allele Detail

Summary

• Symbol: Rasa3^hlb381
• Name: RAS p21 protein activator 3; heart, lung and blood 381
• MGI ID: MGI:3575140
• Synonyms: Rasa3^H794L, Rasa3^hlb
• Gene: Rasa3 Location: Chr8:13617218-13727590 bp, - strand Genetic Position: Chr8, 6.29 cM
• Alliance: Rasa3^hlb381 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to T point mutation that results in the amino acid substitution of leucine for histidine at position 794 (H794L), reduced expression of the protein is found in platelets from homozygotes but not heterozygotes, and Western blots fail to detect this protein in reticulocytes or mature red blood cells. (J:221899, J:301035)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rasa3 Mutation: 62 strains or lines available

References

• Original: J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10
• All: 4 reference(s)