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Scarb1Hlb398
Chemically induced Allele Detail
Summary
Symbol: Scarb1Hlb398
Name: scavenger receptor class B, member 1; heart, lung and blood 398
MGI ID: MGI:3575158
Synonyms: Scarb1I179N
Gene: Scarb1  Location: Chr5:125354151-125418082 bp, - strand  Genetic Position: Chr5, 64.11 cM
Alliance: Scarb1Hlb398 page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsA T to A transversion is located in exon 4 at 536 bp from the start site. This transversion results in a isoleucine to asparagine amino acid change. Western blot analysis indicates that protein expression in the liver of homozygous mice is reduced compared to wild-type controls but levels in the adrenals and ovaries are similar to wild-type controls. (J:152482)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scarb1 Mutation:  53 strains or lines available
References
Original:  J:82961 JAX National Heart, Lung and Blood Program for Genomic Applications (PGA), Heritable mouse mutants from the JAX NHLBI ENU Mutagenesis Program. MGI Direct Data Submission. 2003-10;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory