Map1b^tm1Prop
Targeted Allele Detail

Summary

• Symbol: Map1b^tm1Prop
• Name: microtubule-associated protein 1B; targeted mutation 1, Friedrich Propst
• MGI ID: MGI:3575407
• Synonyms: MAP1B^-, MAP1Bdelta93
• Gene: Map1b Location: Chr13:99557954-99653048 bp, - strand Genetic Position: Chr13, 52.9 cM
• Alliance: Map1b^tm1Prop page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97423
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 20.5 kb of sequence including codons 96-2389, comprising exons 3-5 and part of exon 6, were deleted upon the insertion of a neomycin resistance cassette. Transcripts containing exon 5 sequences were not found in analysis of mutants, and both heavy and light chain polypeptides were absent from immunoblots of mutants. Also absent were any truncated amino-terminal proteins encoded by exons 1 or 2. (J:97423)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map1b Mutation: 85 strains or lines available

References

• Original: J:97423 Meixner A, et al., MAP1B is required for axon guidance and Is involved in the development of the central and peripheral nervous system. J Cell Biol. 2000 Dec 11;151(6):1169-78
• All: 10 reference(s)