Ehmt1^tm1Yshk
Targeted Allele Detail

Summary

• Symbol: Ehmt1^tm1Yshk
• Name: euchromatic histone methyltransferase 1; targeted mutation 1, Yoichi Shinkai
• MGI ID: MGI:3575505
• Synonyms: GLP^-
• Gene: Ehmt1 Location: Chr2:24680781-24809658 bp, - strand Genetic Position: Chr2, 16.73 cM
• Alliance: Ehmt1^tm1Yshk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97244
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 5 and part of exon 6 with a neomycin resistance gene. The deleted sequence encodes the catalytic core region of the SET domain. (J:97244)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ehmt1 Mutation: 91 strains or lines available

References

• Original: J:97244 Tachibana M, et al., Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 2005 Apr 1;19(7):815-26
• All: 12 reference(s)