Drd4^{tm1(IL2RA)Tao}
Targeted Allele Detail

Summary

• Symbol: Drd4^{tm1(IL2RA)Tao}
• Name: dopamine receptor D4; targeted mutation 1, Toshihiko Aosaki
• MGI ID: MGI:3575692
• Gene: Drd4 Location: Chr7:140871931-140874868 bp, + strand Genetic Position: Chr7, 86.6 cM
• Alliance: Drd4^{tm1(IL2RA)Tao} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97412
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert the human IL2RA sequence and a neo into exon 2. The absence of wild-type protein was confirmed by RT-PCR. (J:97412)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Drd4^tm1(IL2RA)Tao/Drd4^tm1(IL2RA)Tao	involves: C57BL/6J

Phenotypes:

Affected Systems	hm1
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nervous system	√
abnormal single cell response	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Drd4 Mutation: 33 strains or lines available

References

• Original: J:97412 Shin RM, et al., Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci. 2003 Dec 17;23(37):11662-72
• All: 1 reference(s)