Tg(Cd4-TGFBR2)16Flv
Transgene Detail

Summary

• Symbol: Tg(Cd4-TGFBR2)16Flv
• Name: transgene insertion 16, Richard A Flavell
• MGI ID: MGI:3575738
• Synonyms: CD4dnTGFbetaRII, CD4dnTgfbr2, CD4-dnTGFBRII, CD4dn-TGF-RII, dnTbetaRII, dnTGF-betaRII, dnTGFbetaRII, dnTgfbr2⁺
• Transgene: Tg(Cd4-TGFBR2)16Flv Location: unknown
• Alliance: Tg(Cd4-TGFBR2)16Flv page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Cd4-TGFBR2)16Flv expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TGFBR2 (7048)

  Tgfbr2

  (MGI:98729)

• Mutation details: This transgene contains the mouse CD4 antigen promoter, sequence encoding the extracellular and transmembrane regions, nucleotides -7 and +573, of the human transforming growth factor, beta receptor II (70/80kDa) and a polyadenylation signal. Transgene expression is detected by RT-PCR analysis of thymus tissue, and is at a level sufficient to block TGF-beta signaling specifically in T cells. (J:97554)

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:97554 Gorelik L, et al., Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 2000 Feb;12(2):171-81
• All: 70 reference(s)