Summary |
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Transgene origin |
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Transgene description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Disease models |
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Find Mice (IMSR) |
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Notes |
This is one of 11 lines generated using this transgenic construct. Of the 11, five lines were characterized for their effect on expression of a tetO-lacZ reporter gene in doubly transgenic mice. Such mice, when treated with doxycycline, exhibit 3- or 30-fold elevated levels of beta-galactosidase (b-gal) activity in skin relative to levels in tetO-lacZ singly-transgenic mice. Immunohistochemical staining for b-gal detects expression in skin and hair follicles, specifically in the outer root sheath of hair follicles and, in one line, the basal layer of the epidermis. Lower-level induction occurs in tongue, forestomach and trachea. No significant b-gal is detected in tissues that do not express endogenous keratin 5 or in the absence of doxycycline. (J:65791)
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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