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wrmod1CAST/Ei
QTL Variant Detail
Summary
QTL variant: wrmod1CAST/Ei
Name: wobbler modifier 1; CAST/Ei
MGI ID: MGI:3575922
QTL: wrmod1  Location: Chr14:58179640-101859473 bp  Genetic Position: Chr14, Syntenic
Variant
origin
Strain of Specimen:  CAST/Ei
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele, in conjunction with wr, confers increased neurodegeneration compared to C57BL/6J. (J:89229)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:89229

Animals from a (C57BL/6J-wr x CAST/Ei)F2 intercross were used to map modifiers of the wobbler (wr) mutation. 46 microsatellite markers were screened by interval haplotype analysis in 18 severely affected homozygous mutant F2 animals. A modifier of wr mapped to mouse Chromosome 14. This locus is named wrmod1 and is CAST/Ei-derived. The effect of wrmod1 is aggravated neurodegeneration, increased astrogliosis, and enhanced progression of neurodegeneration.

The Authors used Consomic lines between CAST/Ei and C57BL/6J to confirm and localize wrmod1 to a 29 cM interval between D14Mit154 (21.5 cM) and D14Mit105 (48 cM). The consomic line carries CAST/Ei-derived chromosome 14 DNA on a C57BL/6J genetic background.

The wrmod1 locus is syntenic to human Chromosome 13q14-q22. Previously identified genes located in the wrmod1 interval are Rb1 (41 cM), Pcdh8 (43 cM), Tnfsf11 (45 cM), and Ednrb (51 cM).

References
Original:  J:89229 Ulbrich M, et al., Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse. Neuroreport. 2002 Mar 25;13(4):535-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory