wrmod1^CAST/Ei
QTL Variant Detail

Summary

• QTL variant: wrmod1^CAST/Ei
• Name: wobbler modifier 1; CAST/Ei
• MGI ID: MGI:3575922
• QTL: wrmod1 Location: Chr14:58179640-101859473 bp Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: CAST/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele, in conjunction with wr, confers increased neurodegeneration compared to C57BL/6J. (J:89229)
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:89229

Animals from a (C57BL/6J-wr x CAST/Ei)F2 intercross were used to map modifiers of the wobbler (wr) mutation. 46 microsatellite markers were screened by interval haplotype analysis in 18 severely affected homozygous mutant F2 animals. A modifier of wr mapped to mouse Chromosome 14. This locus is named wrmod1 and is CAST/Ei-derived. The effect of wrmod1 is aggravated neurodegeneration, increased astrogliosis, and enhanced progression of neurodegeneration.

The Authors used Consomic lines between CAST/Ei and C57BL/6J to confirm and localize wrmod1 to a 29 cM interval between D14Mit154 (21.5 cM) and D14Mit105 (48 cM). The consomic line carries CAST/Ei-derived chromosome 14 DNA on a C57BL/6J genetic background.

The wrmod1 locus is syntenic to human Chromosome 13q14-q22. Previously identified genes located in the wrmod1 interval are Rb1 (41 cM), Pcdh8 (43 cM), Tnfsf11 (45 cM), and Ednrb (51 cM).

References

• Original: J:89229 Ulbrich M, et al., Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse. Neuroreport. 2002 Mar 25;13(4):535-9
• All: 1 reference(s)