Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:89229Animals from a (C57BL/6J-wr x CAST/Ei)F2 intercross were used to map modifiers of the wobbler (wr) mutation. 46 microsatellite markers were screened by interval haplotype analysis in 18 severely affected homozygous mutant F2 animals. A modifier of wr mapped to mouse Chromosome 14. This locus is named wrmod1 and is CAST/Ei-derived. The effect of wrmod1 is aggravated neurodegeneration, increased astrogliosis, and enhanced progression of neurodegeneration. The Authors used Consomic lines between CAST/Ei and C57BL/6J to confirm and localize wrmod1 to a 29 cM interval between D14Mit154 (21.5 cM) and D14Mit105 (48 cM). The consomic line carries CAST/Ei-derived chromosome 14 DNA on a C57BL/6J genetic background.The wrmod1 locus is syntenic to human Chromosome 13q14-q22. Previously identified genes located in the wrmod1 interval are Rb1 (41 cM), Pcdh8 (43 cM), Tnfsf11 (45 cM), and Ednrb (51 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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