Igf1r^hyft
Chemically induced Allele Detail

Summary

• Symbol: Igf1r^hyft
• Name: insulin-like growth factor I receptor; hydrops fetalis
• MGI ID: MGI:3576029
• Synonyms: line 186
• Gene: Igf1r Location: Chr7:67602575-67883416 bp, + strand Genetic Position: Chr7, 37.27 cM
• Alliance: Igf1r^hyft page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, which was identified in an ENU mutagenesis screen, is due to a T-to-A transversion in exon 13 that introduces a premature stop codon upstream of the sequence encoding the transmembrane and kinase domains. Western blot analysis of protein extracts from homozygous mutant 18.5 dpc embryos and newborn mice detected no IGF1R protein. (J:105913)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igf1r Mutation: 88 strains or lines available

References

• Original: J:75360 Herron BJ, et al., Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. Nat Genet. 2002 Feb;30(2):185-9
• All: 2 reference(s)