Cyp27b1^tm1Hfd
Targeted Allele Detail

Summary

• Symbol: Cyp27b1^tm1Hfd
• Name: cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1, Hector F DeLuca
• MGI ID: MGI:3576226
• Gene: Cyp27b1 Location: Chr10:126884119-126888875 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Cyp27b1^tm1Hfd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97370
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the coding region was replaced by lacZ and neomycin resistance genes. Absence of transcript in mutants was confirmed by RT-PCR of total kidney RNA. (J:104572)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp27b1 Mutation: 33 strains or lines available

References

• Original: J:97370 Healy KD, et al., Parathyroid hormone decreases renal vitamin D receptor expression in vivo. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4724-8
• All: 11 reference(s)