Fxyd1^tm1Atck
Targeted Allele Detail

Summary

• Symbol: Fxyd1^tm1Atck
• Name: FXYD domain-containing ion transport regulator 1; targeted mutation 1, Amy L Tucker
• MGI ID: MGI:3576231
• Synonyms: PLM^-, PLM-KO
• Gene: Fxyd1 Location: Chr7:30751103-30756624 bp, - strand Genetic Position: Chr7, 19.29 cM, cytoband B1
• Alliance: Fxyd1^tm1Atck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97365
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An NLS-lacZ and a neo cassette were inserted to replace part of exon 3 and all of exons 4 and 5, sequence that encodes the entire transmembrane domain. Mutant hearts were analyzed by Western blot and demonstrated a lack of protein. (J:97365)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fxyd1 Mutation: 26 strains or lines available

References

• Original: J:97365 Jia LG, et al., Hypertrophy, increased ejection fraction, and reduced Na-K-ATPase activity in phospholemman-deficient mice. Am J Physiol Heart Circ Physiol. 2005 Apr;288(4):H1982-8
• All: 20 reference(s)