Ptgs1^tm1Fun
Targeted Allele Detail

Summary

• Symbol: Ptgs1^tm1Fun
• Name: prostaglandin-endoperoxide synthase 1; targeted mutation 1, Colin D Funk
• MGI ID: MGI:3576237
• Synonyms: COX-1 KD, PGHS1^Neo
• Gene: Ptgs1 Location: Chr2:36120438-36142284 bp, + strand Genetic Position: Chr2, 24.19 cM
• Alliance: Ptgs1^tm1Fun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97351
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A floxed PGK-neo was inserted into intron 10 to create this hypomorphic allele. Western blot showed that protein was dramatically reduced in mutant macrophages to approximately 10% of wild-type levels. (J:97351)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgs1 Mutation: 46 strains or lines available

References

• Original: J:97351 Yu Y, et al., Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest. 2005 Apr 1;115(4):986-995
• All: 9 reference(s)