Chfr^tm1Jc
Targeted Allele Detail

Summary

• Symbol: Chfr^tm1Jc
• Name: checkpoint with forkhead and ring finger domains; targeted mutation 1, Junjie Chen
• MGI ID: MGI:3576266
• Synonyms: Chfr^-
• Gene: Chfr Location: Chr5:110283708-110319838 bp, + strand Genetic Position: Chr5, 53.32 cM
• Alliance: Chfr^tm1Jc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97428
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the exon spanning nt 132-237 that encodes part of the FHA domain. Immunoblotting of mutant MEFs confirmed lack of protein. (J:97428)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Chfr^tm1Jc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chfr Mutation: 39 strains or lines available

References

• Original: J:97428 Yu X, et al., Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr;37(4):401-6
• All: 4 reference(s)