Pla2g15^tm1Ytan
Targeted Allele Detail

Summary

• Symbol: Pla2g15^tm1Ytan
• Name: phospholipase A2, group XV; targeted mutation 1, Yoshio Taniyama
• MGI ID: MGI:3576269
• Synonyms: LLPL^-
• Gene: Pla2g15 Location: Chr8:106877031-106891347 bp, + strand Genetic Position: Chr8, 53.1 cM
• Alliance: Pla2g15^tm1Ytan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97471
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exons 3-5 were disrupted by the insertion of a neomycin resistance gene. No protein was detected by immunoprecipitation of thioglycollate-elicited peritoneal macrophages. (J:97471)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g15 Mutation: 30 strains or lines available

References

• Original: J:97471 Taniyama Y, et al., Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun. 2005 Apr 29;330(1):104-10
• All: 1 reference(s)