Foxp3^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1Flv
• Name: forkhead box P3; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:3576270
• Synonyms: FIR, Foxp3^IRES-mrfp, Foxp3-IRES-mRFP, Foxp3-IRES-RFP, Foxp3-RFP, Foxp3/RFP
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97415
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A targeting cassette containing an IRES-mRFP and a floxed neo was inserted between the translation stop codon and the polyA signal of the locus. Crossing with cre deleter mice removed the neo. Flow cytometry revealed mRFP expression occurred where Foxp3 is normally expressed. (J:97415)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:97415 Wan YY, et al., Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5126-31
• All: 187 reference(s)