Cald1^tm1Claw
Targeted Allele Detail

Summary

• Symbol: Cald1^tm1Claw
• Name: caldesmon 1; targeted mutation 1, C-L Albert Wang
• MGI ID: MGI:3576365
• Gene: Cald1 Location: Chr6:34575433-34752404 bp, + strand Genetic Position: Chr6, 15.07 cM
• Alliance: Cald1^tm1Claw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97432
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct containing three tandem stop codons in exon 3b and a neomycin resistance gene was inserted to interrupt transcription of the smooth muscle isoform. Exons 4 and 5 were deleted upon recombination. Lung, bladder, intestine and uterus of mutants showed the lack of smooth muscle isoform in Western blot analyses. The non-muscle isoform was translated at normal levels. (J:97432)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cald1 Mutation: 38 strains or lines available

References

• Original: J:97432 Guo H, et al., Specific disruption of smooth muscle caldesmon expression in mice. Biochem Biophys Res Commun. 2005 May 20;330(4):1132-7
• All: 2 reference(s)