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Cald1tm1Claw
Targeted Allele Detail
Summary
Symbol: Cald1tm1Claw
Name: caldesmon 1; targeted mutation 1, C-L Albert Wang
MGI ID: MGI:3576365
Gene: Cald1  Location: Chr6:34575433-34752404 bp, + strand  Genetic Position: Chr6, 15.07 cM
Alliance: Cald1tm1Claw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97432
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA construct containing three tandem stop codons in exon 3b and a neomycin resistance gene was inserted to interrupt transcription of the smooth muscle isoform. Exons 4 and 5 were deleted upon recombination. Lung, bladder, intestine and uterus of mutants showed the lack of smooth muscle isoform in Western blot analyses. The non-muscle isoform was translated at normal levels. (J:97432)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cald1 Mutation:  37 strains or lines available
References
Original:  J:97432 Guo H, et al., Specific disruption of smooth muscle caldesmon expression in mice. Biochem Biophys Res Commun. 2005 May 20;330(4):1132-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory