Izumo1^tm1Osb
Targeted Allele Detail

Summary

• Symbol: Izumo1^tm1Osb
• Name: izumo sperm-egg fusion 1; targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
• MGI ID: MGI:3576382
• Synonyms: Izumo^-, Izumo1^tm1Oka
• Gene: Izumo1 Location: Chr7:45270251-45276653 bp, + strand Genetic Position: Chr7, 29.39 cM, cytoband B2
• Alliance: Izumo1^tm1Osb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97563
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene placed in the reverse orientation to transcription replaced exons 2-10. Mutants demonstrated lack of transcript and protein in Northern blot and Western blot analyses of testes and sperm, respectively. (J:97563)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Izumo1 Mutation: 24 strains or lines available

References

• Original: J:97563 Inoue N, et al., The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature. 2005 Mar 10;434(7030):234-8
• All: 13 reference(s)