Gata6tm1Sad
Targeted Allele Detail
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Symbol: |
Gata6tm1Sad |
Name: |
GATA binding protein 6; targeted mutation 1, Stephen A Duncan |
MGI ID: |
MGI:3576383 |
Synonyms: |
Gata6- |
Gene: |
Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
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Alliance: |
Gata6tm1Sad page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5 which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele.
(J:97579)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S1/Sv * 129X1/SvJ | |
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Phenotypes: |
Affected Systems |
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cardiovascular system
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N
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cardiovascular system phenotype
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N
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embryo
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√
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decreased embryo size
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√
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growth/size/body
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√
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decreased embryo size
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√
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liver/biliary system
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√
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abnormal liver bud morphology
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√
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mortality/aging
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√
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embryonic lethality during organogenesis, complete penetrance
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gata6 Mutation: |
35 strains or lines available
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The original reference (J:97579) used ES cell derived embryos only and did not indicate if a line of mice was generated for this allele
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Original: |
J:97579 Zhao R, et al., GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31 |
All: |
1 reference(s) |
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