Gata6^tm1Sad
Targeted Allele Detail

Summary

• Symbol: Gata6^tm1Sad
• Name: GATA binding protein 6; targeted mutation 1, Stephen A Duncan
• MGI ID: MGI:3576383
• Synonyms: Gata6^-
• Gene: Gata6 Location: Chr18:11052510-11085636 bp, + strand Genetic Position: Chr18, 5.63 cM
• Alliance: Gata6^tm1Sad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97579
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 4 and 5 which encode the zinc finger domains of the encoded protein. In situ hybridization experiments on homozygous embryos demonstrated that no detectable transcript was produced from this allele. (J:97579)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata6 Mutation: 35 strains or lines available

Notes

The original reference (J:97579) used ES cell derived embryos only and did not indicate if a line of mice was generated for this allele

References

• Original: J:97579 Zhao R, et al., GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol. 2005 Apr;25(7):2622-31
• All: 1 reference(s)