Irf5^tm1Ttg
Targeted Allele Detail

Summary

• Symbol: Irf5^tm1Ttg
• Name: interferon regulatory factor 5; targeted mutation 1, Tadatsugu Taniguchi
• MGI ID: MGI:3576384
• Synonyms: Irf5^-
• Gene: Irf5 Location: Chr6:29526624-29541870 bp, + strand Genetic Position: Chr6, 12.36 cM
• Alliance: Irf5^tm1Ttg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97567
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced sequence-encoding part of the DNA-binding domain in exon 2. Northern blot and immunoblot analyses confirmed absence of transcript and protein, in mutant MEFs and splenocytes, respectively. (J:97567)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf5 Mutation: 28 strains or lines available

Notes

Dock2^mu was confirmed to be present in two Irf5^tm1Ttg lines from the USA but not one line from Japan. J:182658

References

• Original: J:97567 Takaoka A, et al., Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature. 2005 Mar 10;434(7030):243-9
• All: 59 reference(s)