Smurf1^tm1Yez
Targeted Allele Detail

Summary

• Symbol: Smurf1^tm1Yez
• Name: SMAD specific E3 ubiquitin protein ligase 1; targeted mutation 1, Ying E Zhang
• MGI ID: MGI:3576775
• Synonyms: Smurf^-
• Gene: Smurf1 Location: Chr5:144813305-144902657 bp, - strand Genetic Position: Chr5, 84.83 cM, cytoband G2
• Alliance: Smurf1^tm1Yez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97303
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace three exons with a neomycin resistance gene, thereby generating a truncated protein product lacking two highly concerved WW domains and the HECT ubiquitin ligase domain. (J:97303)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smurf1 Mutation: 55 strains or lines available

References

• Original: J:97303 Yamashita M, et al., Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation. Cell. 2005 Apr 8;121(1):101-13
• All: 9 reference(s)