Rax^tm1.2Lwd
Targeted Allele Detail

Summary

• Symbol: Rax^tm1.2Lwd
• Name: retina and anterior neural fold homeobox; targeted mutation 1.2, Mark Lewandoski
• MGI ID: MGI:3576779
• Synonyms: Rx^delta2
• Gene: Rax Location: Chr18:66067710-66072160 bp, - strand Genetic Position: Chr18, 39.03 cM
• Alliance: Rax^tm1.2Lwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97314
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing Rax^tm1Lwd mice with cre-deleter mice removed exon 2 in the germ line, leaving exon 3 out of frame and causing the creation of a truncated, nonfunctional protein lacking the homeodomain. (J:97314)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rax Mutation: 16 strains or lines available

References

• Original: J:97314 Voronina VA, et al., Conditional alleles for activation and inactivation of the mouse Rx homeobox gene. Genesis. 2005 Apr;41(4):160-4
• All: 3 reference(s)