Vegfd^tm1Mach
Targeted Allele Detail

Summary

• Symbol: Vegfd^tm1Mach
• Name: vascular endothelial growth factor D; targeted mutation 1, Marc G Achen
• MGI ID: MGI:3576785
• Synonyms: Vegfd^lz
• Gene: Vegfd Location: ChrX:163156374-163185646 bp, + strand Genetic Position: ChrX, 76.35 cM
• Alliance: Vegfd^tm1Mach page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97571
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-pgk-neo cassette was inserted to replace the signal sequence in exon 1 downstream of the translation start site. Northern blot demonstrated lack of expression in mutant E15.5 lungs. Western block confirmed lack of protein in mutants. (J:97571)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vegfd Mutation: 15 strains or lines available

References

• Original: J:97571 Baldwin ME, et al., Vascular endothelial growth factor D is dispensable for development of the lymphatic system. Mol Cell Biol. 2005 Mar;25(6):2441-9
• All: 13 reference(s)