Angptl6^tm1Yo
Targeted Allele Detail

Summary

• Symbol: Angptl6^tm1Yo
• Name: angiopoietin-like 6; targeted mutation 1, Yuichi Oike
• MGI ID: MGI:3576787
• Synonyms: AGF^-
• Gene: Angptl6 Location: Chr9:20785104-20791023 bp, - strand Genetic Position: Chr9, 7.66 cM, cytoband A3
• Alliance: Angptl6^tm1Yo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97552
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo was inserted to replace the 5' UTR. Northern blot and Western blot demonstrated lack of transcript and protein, respectively, in mutants. (J:97552)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl6 Mutation: 19 strains or lines available

References

• Original: J:97552 Oike Y, et al., Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med. 2005 Apr;11(4):400-8
• All: 1 reference(s)