Drd2^tm1Mok
Targeted Allele Detail

Summary

• Symbol: Drd2^tm1Mok
• Name: dopamine receptor D2; targeted mutation 1, Motoya Katsuki
• MGI ID: MGI:3576789
• Synonyms: D2KO
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm1Mok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97838
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' end of exon 2, containing the ATG, was replaced by a neomycin resistance gene to prevent production of either of two possible isoforms. In situ hybridization demonstrated no expression of mRNA in mutant brain samples. (J:97838)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 19 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:97838 Yamaguchi H, et al., Dopamine D2 receptor plays a critical role in cell proliferation and proopiomelanocortin expression in the pituitary. Genes Cells. 1996 Feb;1(2):253-68
• All: 12 reference(s)