Myh11^tm1Peri
Targeted Allele Detail

Summary

• Symbol: Myh11^tm1Peri
• Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1, Muthu Periasamy
• MGI ID: MGI:3576856
• Synonyms: smb^-
• Gene: Myh11 Location: Chr16:14012392-14109227 bp, - strand Genetic Position: Chr16, 9.71 cM
• Alliance: Myh11^tm1Peri page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5b was replaced with a PGK-neo cassette. RNase protection and Western blot confirmed successful ablation of the SM-B isoform. (J:97927)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh11 Mutation: 94 strains or lines available

References

• Original: J:97927 Babu GJ, et al., Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol. 2001 Nov;3(11):1025-9
• All: 7 reference(s)