Birc2^tm1Jda
Targeted Allele Detail

Summary

• Symbol: Birc2^tm1Jda
• Name: baculoviral IAP repeat-containing 2; targeted mutation 1, Jonathan D Ashwell
• MGI ID: MGI:3576924
• Synonyms: c-IAP1^-
• Gene: Birc2 Location: Chr9:7818228-7837065 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Birc2^tm1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97656
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a portion of exon 1 containing the first baculovirus IAP repeat, the transcription start codon and sequences encoding the the first BIR domain. Immunoblot of mutant spleen and thymus whole cell lysates confirmed absence of protein. (J:97656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Birc2 Mutation: 33 strains or lines available

References

• Original: J:97656 Conze DB, et al., Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol. 2005 Apr;25(8):3348-56
• All: 11 reference(s)